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•    Gargatte S, Li Z, Zhou Y, Wang X, Zhuang L, Zhang H*. Utilizing a tyrosine exporter to facilitate 4-hydroxystyrene biosynthesis in an E. coli-E. coli co-culture. Biochemical Engineering Journal. accepted for publication.


•    Chen T, Wang X, Zhuang L, Shao A, Lu Y, Zhang H*. Development and optimization of a microbial co-culture system for heterologous indigo biosynthesis. Microbial Cell Factories. 2021. 20, 154.


•   Chopda V,  Gyorgypal A. Yang O, Singh R, Ramachandran R, Zhang H, Tsilomelekis G, Chundawat S, Ierapetritou M. Recent Advances in Integrated Process Analytical Techniques, Modeling, and Control Strategies to Enable Continuous Biomanufacturing of Monoclonal Antibodies. Journal of Chemical Technology and Biotechnology. In press.


•    Zhuang L, Zhang H*. Utilizing cross-species co-cultures for discovery of novel natural products. Current Opinion in Biotechnology. 2021. 69: 252-262.


•    Liu Y, Caruso J, Zhang H*. Developing an effective approach for microbial biosynthesis of hydroxyhydroquinone. Biochemical Engineering Journal. 2021. 168:  107929.


•    Hua K, Liu X, Zhao Y, Gao Y, Pan L, Zhang H, Deng Z, Jiang M. Offloading role of a discrete thioesterase in type II polyketide biosynthesis. mBio. 2020. 11 (5): e01334-2.


•    Li Z, Zuber A, Wang X, Marlowe J, Vekaria A, Lu Y, Zhang H*, Tsilomelekis G*. Towards the coupling of microbial biosynthesis and catalysis for the production of alkylated phenolic compounds. AICHE Journal. 2020. 66: e16547.


•    Li Z, Lu Y, Wang X, Vekaria A, Jiang M, Zhang H*. Enhancing anthranilic acid biosynthesis using biosensor-assisted cell selection and in situ product removal. Biochemical Engineering Journal. 2020. 162: 107722.


•    Wang X, Shao A, Li Z, Policarpio L, Zhang H*. Constructing E. coli co-cultures for de novo biosynthesis of natural product acacetin. Biotechnology Journal. 2020. 15: 2000131.


•    Wang X, Li Z, Policarpio L, Koffas M, Zhang H*. De novo biosynthesis of complex natural product sakuranetin using modular co-culture engineering. Applied Microbiology and Biotechnology. 2020. 104: 4849-4861.


•    Guo X, Wang X, Chen T, Lu Y, Zhang H*. Comparing E. coli mono-cultures and co-cultures for biosynthesis of protocatechuic acid and hydroquinone. Biochemical Engineering Journal. 2020. 756: 107518.


•    Liu X, Hua K, Liu D, Wu ZL, Wang Y, Zhang H, Deng Z, Pfeifer B, Jiang M. Heterologous biosynthesis of type II polyketide products using E. coli. ACS Chemical Biology. 2020. 15: 1177-1183.


•    Wang X, Policarpio L, Prajapati D, Li Z, Zhang H*. Developing E. coli-E. coli co-cultures to overcome barriers of heterologous tryptamine biosynthesis. Metabolic Engineering Communications. 2020. 10: e00110.


•     Guo X, Li Z, Wang X, Wang J, Chala J, Lu Y, Zhang H*. De novo phenol bioproduction from glucose using biosensor-assisted microbial co-culture engineering. Biotechnology and Bioengineering. 2019. 116: 3349-3359.


 •    Zhou Y, Li Z, Wang X, Zhang H*. Establishing microbial co-cultures for 3-hydroxybenzoic acid biosynthesis on glycerol. Engineering in Life Sciences. 2019. 19: 389-395.

 

•     Li Z, Wang X, Zhang H*. Balancing the non-linear rosmarinic acid biosynthetic pathway by modular co-culture engineering. Metabolic Engineering. 2019. 54: 1-11.

 

 •    Wang X, Cabales A, Li Z, Zhang H*. Biosensor-assisted high performing cell selection using an E. coli toxin/antitoxin system. Biochemical Engineering Journal. 2019. 144: 110-118.

 

 •    Chen T, Zhou Y, Lu Y, Zhang H*. Advances in heterologous biosynthesis of plant and fungal natural products by modular co-culture engineering. Biotechnology Letters. 2019. 41(1): 27-34.

 

 •    Ganesan V, Li Z, Wang X, Zhang H*. Heterologous biosynthesis of natural product naringenin by co-culture engineering. Synthetic and Systems Biotechnology. 2017. 2(3): 236-242.

 

 •    Zhang H*, Wang X. Modular co-culture engineering, a new approach for metabolic engineering. Metabolic Engineering. 2016. 37: 114-121.

 

 •    Zhang H*, Stephanopoulos G*. Co-culture engineering for microbial biosynthesis of 3-amino-benzoic acid in E. coli. Biotechnology Journal. 2016. 11(7): 981-987.

 

 •    Jiang M*, Zhang H*. Engineering the shikimate pathway for biosynthesis of molecules with pharmaceutical activities in E. coli. Current Opinion in Biotechnology. 2016. 42: 1-6.


Before joining Rutgers


 •    Li Z, Qiao K, Shi W, Pereira B, Zhang H, Olsen B, Stephanopoulos G. Biosynthesis of novel glycolate-containing polymers from glucose by metabolically engineered Escherichia coli. Metabolic Engineering. 2016. 35: 1-8.

 

 •    Pereira B, Li Z, De Mey M, Lim CG, Zhang H, Hoeltgen C, Stephanopoulos G. Efficient utilization of pentoses for the bioproduction of renewable two-carbon compounds, ethylene glycol and glycolate. Metabolic Engineering. 2016. 34: 80-87.

 

 •    Pereira B, Zhang H, De Mey M, Lim CG, Li Z, Stephanopoulos G. Engineering a novle biosynthetic pathway in Escherichia coli for production of renewable ethylene glycol. Biotechnology and Bioengineering. 2016. 113: 376-383.

 

 •    Zhang H, Fang L, Osburne M, Pfeifer B. The continuing development of E. coli as a heterologous host for complex natural product. Nonribosomal Peptide and Polyketide Biosynthesis: Methods and Protocols. Methods in Molecular Biology. 2016. 1401: 121-134.

 

 •    Zhang H, Li Z, Pereira B, Stephanopoulos G. Engineering E. coli-E. coli cocultures for production of muconic acid from glycerol. Microbial Cell Factories. 2015. 14: 134.

 

 •    Zhang H, Pereira B, Li Z, Stephanopoulos G. Engineering Escherichia coli coculture systems for the production of biochemical products. Proceedings of the National Academy of Sciences of the United States of America. 2015. 112: 8266-8271.

 

 •    Qiao K, Abidi S, Liu H, Zhang H, Chakraborty S, Watson N, Ajikumar PK, Stephanopoulos G. Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica. Metabolic Engineering. 2015. 29: 56-65.

 

 •    Zhang H, Stephanopoulos G. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Applied Microbiology and Biotechnology. 2013. 97(8): 3333-3341.

 

    Jiang M, Zhang H, Park S, Li Y, Pfeifer B. Deoxysugar pathway interchange for erythromycin analogues heterologously produced through E. coli. Metabolic Engineering. 2013. 20: 92-100.

 

    Jiang M, Zhang H, Pfeifer B. The logic, experimental steps, and potential of heterologous natural product biosynthesis featuring the complex antibiotic erythromycin A produced through E. coli. The Journal of Visualized Experiments. 2013. (71): e4346.

 

 •    Zhang H, Skalina K, Jiang M, Pfeifer B. Improved E. coli erythromycin A production through the application of metabolic and bioprocess engineering. Biotechnology Progress. 2012. 28(1): 292-296.

 

 •    Zhang H, Boghigian B, Armando J, Pfeifer B. Methods and options for the heterologous production of complex natural products. Natural Product Reports. 2011. 28(1): 125-151.

 

 •    Boghigian B, Zhang H, Pfeifer B. Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnology and Bioengineering. 2011. 108(6): 1360-1371.

 

 •    Zhang H, Wang Y, Wu J, Pfeifer B. Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host. Chemistry and Biology. 2010. 17: 1232-1240.

 

 •    Zhang H, Boghigian B, Pfeifer B. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. Biotechnology and Bioengineering. 2010. 105(3): 567-573.

 

 •    Wu J, Boghigian B, Myint M, Zhang H, Pfeifer B. Construction and performance of heterologous polyketide producing K-12 and B-derived Escherichia coli. Letters in Applied Microbiology. 2010. 51: 196-204.

 

     Zhang H, Wang Y, Boghigian B, Pfeifer B. Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. Microbial Biotechnology. 2009. 2(3): 390-394. 

 

 •     Zhang H, Wang Y, Pfeifer B. Bacterial hosts for natural product production. Molecular Pharmaceutics. 2008. 5(2): 212-225.

 

 •     Zhang H, Li Q, Wang H, Sun D, Lu Y, He N. Accumulation of silver(I) ion and diamine silver complex by Aeromonas SH10 biomass. Applied Biochemistry and Biotechnology. 2007. 143: 54-62.

 

•     Zhang H, Li Q, Lu Y, Lin X, Deng X, He N, Zheng S. Biosorption and bioreduction of diamine silver complex by Corynebacterium. Journal of Chemical Technology & Biotechnology. 2005. 80(3): 285-290.

 

 •     Zhang H, Li Q, Sun D, Lin X, Deng X, Lu Y, He N. The preparation of silver nanoparticles. Precious Metals. 2005. 26(2): 51-56.

       


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Chemical and Biochemical Engineering DepartmentSchool of EngineeringRutgers University