• Akdemir H, Liu Y, Zhuang L, Zhang H*, Koffas M. Utilization of microbial cocultures for converting mixed substrates to valuable bioproducts. Current Opinion in Microbiology. 2022. 68.
• Gargatte S, Li Z, Zhou Y, Wang X, Zhuang L, Zhang H*. Utilizing a tyrosine exporter to facilitate 4-hydroxystyrene biosynthesis in an E. coli-E. coli co-culture. Biochemical Engineering Journal. 2021. 176.
• Chen T, Wang X, Zhuang L, Shao A, Lu Y, Zhang H*. Development and optimization of a microbial co-culture system for heterologous indigo biosynthesis. Microbial Cell Factories. 2021. 20, 154.
• Chopda V, Gyorgypal A. Yang O, Singh R, Ramachandran R, Zhang H, Tsilomelekis G, Chundawat S, Ierapetritou M. Recent
Advances in Integrated Process Analytical Techniques, Modeling, and
Control Strategies to Enable Continuous Biomanufacturing of Monoclonal
Antibodies. Journal of Chemical Technology and Biotechnology. In press.
• Zhuang L, Zhang H*. Utilizing cross-species co-cultures for discovery of novel natural products. Current Opinion in Biotechnology. 2021. 69: 252-262.
• Liu Y, Caruso J, Zhang H*. Developing an effective approach for microbial biosynthesis of hydroxyhydroquinone. Biochemical Engineering Journal. 2021. 168: 107929.
• Hua K, Liu X, Zhao Y, Gao Y, Pan L, Zhang H, Deng Z, Jiang M. Offloading role of a discrete thioesterase in type II polyketide biosynthesis. mBio. 2020. 11 (5): e01334-2.
• Li Z, Zuber A, Wang
X, Marlowe J, Vekaria A, Lu Y, Zhang H*, Tsilomelekis G*. Towards
the coupling of microbial biosynthesis and catalysis for the production
of alkylated phenolic compounds. AICHE Journal. 2020. 66: e16547.
• Li Z, Lu Y, Wang X, Vekaria A, Jiang M, Zhang H*. Enhancing anthranilic acid biosynthesis using biosensor-assisted cell selection and in situ product removal. Biochemical Engineering Journal. 2020. 162: 107722.
• Wang X, Shao A, Li Z, Policarpio L, Zhang H*. Constructing E. coli co-cultures for de novo biosynthesis of natural product acacetin. Biotechnology Journal. 2020. 15: 2000131.
• Wang X, Li Z, Policarpio L, Koffas M, Zhang H*. De novo biosynthesis of complex natural product sakuranetin using modular co-culture engineering. Applied Microbiology and Biotechnology. 2020. 104: 4849-4861.
• Guo X, Wang X, Chen T, Lu Y, Zhang H*. Comparing E. coli mono-cultures and co-cultures for biosynthesis of protocatechuic acid and hydroquinone. Biochemical Engineering Journal. 2020. 756: 107518.
•
Liu X, Hua K, Liu D, Wu ZL, Wang Y, Zhang H, Deng Z, Pfeifer B, Jiang
M. Heterologous biosynthesis of type II polyketide products using E. coli. ACS Chemical Biology. 2020. 15: 1177-1183.
•
Wang X, Policarpio L, Prajapati D, Li Z, Zhang H*. Developing E.
coli-E. coli co-cultures to overcome barriers of heterologous
tryptamine biosynthesis. Metabolic Engineering Communications. 2020. 10: e00110.
• Guo X, Li Z, Wang X, Wang J, Chala J, Lu Y, Zhang H*. De novo phenol bioproduction from glucose using biosensor-assisted microbial co-culture engineering. Biotechnology and Bioengineering. 2019. 116: 3349-3359.
• Zhou Y, Li Z, Wang X, Zhang H*. Establishing microbial co-cultures for 3-hydroxybenzoic acid biosynthesis on glycerol. Engineering in Life Sciences. 2019. 19: 389-395.
• Li
Z, Wang X, Zhang H*. Balancing the non-linear rosmarinic acid
biosynthetic pathway by modular co-culture engineering. Metabolic Engineering. 2019. 54: 1-11.
• Wang X, Cabales A, Li Z, Zhang H*. Biosensor-assisted high performing cell selection using an E. coli toxin/antitoxin system. Biochemical Engineering Journal. 2019. 144: 110-118.
• Chen T, Zhou Y, Lu Y, Zhang H*. Advances in heterologous biosynthesis
of plant and fungal natural products by modular co-culture engineering.
Biotechnology Letters. 2019. 41(1): 27-34.
•
Ganesan V, Li Z, Wang X, Zhang H*. Heterologous biosynthesis of natural
product naringenin by co-culture engineering. Synthetic and Systems
Biotechnology. 2017. 2(3): 236-242.
• Zhang
H*, Wang X. Modular co-culture engineering, a new approach for metabolic
engineering. Metabolic Engineering. 2016. 37: 114-121.
• Zhang
H*, Stephanopoulos G*. Co-culture engineering for microbial biosynthesis of
3-amino-benzoic acid in E. coli. Biotechnology Journal. 2016.
11(7): 981-987.
• Jiang M*, Zhang H*. Engineering
the shikimate pathway for biosynthesis of molecules with pharmaceutical
activities in E. coli. Current Opinion in Biotechnology. 2016.
42: 1-6.
Before joining Rutgers
• Li Z, Qiao K, Shi
W, Pereira B, Zhang H, Olsen B, Stephanopoulos G.
Biosynthesis of novel glycolate-containing polymers from glucose by
metabolically engineered Escherichia coli. Metabolic Engineering.
2016. 35: 1-8.
• Pereira B, Li Z, De
Mey M, Lim CG, Zhang H, Hoeltgen C, Stephanopoulos G.
Efficient utilization of pentoses for the bioproduction of renewable two-carbon
compounds, ethylene glycol and glycolate. Metabolic Engineering. 2016.
34: 80-87.
• Pereira B, Zhang H, De
Mey M, Lim CG, Li Z, Stephanopoulos G. Engineering a novle
biosynthetic pathway in Escherichia coli for production of renewable
ethylene glycol. Biotechnology and Bioengineering. 2016. 113: 376-383.
• Zhang H, Fang L, Osburne M, Pfeifer B.
The continuing development of E. coli as a heterologous host for complex
natural product. Nonribosomal Peptide and Polyketide Biosynthesis: Methods
and Protocols. Methods in Molecular Biology. 2016. 1401: 121-134.
• Zhang H, Li
Z, Pereira B, Stephanopoulos G. Engineering E. coli-E. coli
cocultures for production of muconic acid from glycerol. Microbial Cell
Factories. 2015. 14: 134.
• Zhang H, Pereira B, Li
Z, Stephanopoulos G. Engineering Escherichia coli coculture systems
for the production of biochemical products. Proceedings of the National
Academy of Sciences of the United States of America. 2015. 112: 8266-8271.
• Qiao K, Abidi S, Liu
H, Zhang H, Chakraborty S, Watson N, Ajikumar
PK, Stephanopoulos G. Engineering lipid overproduction in the oleaginous
yeast Yarrowia lipolytica. Metabolic Engineering. 2015. 29:
56-65.
• Zhang H, Stephanopoulos G.
Engineering E. coli for caffeic acid biosynthesis from renewable sugars.
Applied Microbiology and Biotechnology. 2013. 97(8): 3333-3341.
• Jiang M, Zhang H, Park S, Li
Y, Pfeifer B. Deoxysugar pathway interchange for erythromycin analogues
heterologously produced through E. coli. Metabolic Engineering.
2013. 20: 92-100.
• Jiang M, Zhang H, Pfeifer B.
The logic, experimental steps, and potential of heterologous natural product
biosynthesis featuring the complex antibiotic erythromycin A produced through E.
coli. The Journal of Visualized Experiments. 2013. (71): e4346.
• Zhang H, Skalina K,
Jiang M, Pfeifer B. Improved E. coli erythromycin A production through
the application of metabolic and bioprocess engineering. Biotechnology
Progress. 2012. 28(1): 292-296.
• Zhang H, Boghigian
B, Armando J, Pfeifer B. Methods and options for the heterologous
production of complex natural products. Natural Product Reports. 2011.
28(1): 125-151.
• Boghigian B, Zhang H,
Pfeifer B. Multi-factorial engineering of heterologous polyketide production in
Escherichia coli reveals complex pathway interactions. Biotechnology
and Bioengineering. 2011. 108(6): 1360-1371.
• Zhang H, Wang Y, Wu J, Pfeifer B. Complete biosynthesis
of erythromycin A and designed analogs using E. coli as a heterologous
host. Chemistry and Biology. 2010. 17: 1232-1240.
• Zhang H, Boghigian B, Pfeifer B. Investigating the
role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous
polyketide production in Escherichia coli. Biotechnology and
Bioengineering. 2010. 105(3): 567-573.
• Wu J, Boghigian B, Myint
M, Zhang H, Pfeifer B. Construction and performance of heterologous polyketide
producing K-12 and B-derived Escherichia coli. Letters in Applied
Microbiology. 2010. 51: 196-204.
• Zhang H, Wang Y, Boghigian B, Pfeifer B. Probing the
heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia
coli. Microbial Biotechnology. 2009. 2(3): 390-394.
• Zhang H, Wang Y, Pfeifer B. Bacterial hosts for natural product
production. Molecular Pharmaceutics. 2008. 5(2): 212-225.
• Zhang H, Li Q, Wang H, Sun D, Lu
Y, He N. Accumulation of silver(I) ion and diamine silver complex by Aeromonas
SH10 biomass. Applied Biochemistry and Biotechnology. 2007. 143: 54-62.
•
Zhang H, Li Q, Lu Y, Lin X, Deng X, He N, Zheng S. Biosorption and bioreduction of
diamine silver complex by Corynebacterium. Journal of Chemical
Technology & Biotechnology. 2005. 80(3): 285-290.
• Zhang H, Li Q, Sun D, Lin X, Deng
X, Lu Y, He N. The preparation of silver nanoparticles. Precious
Metals. 2005. 26(2): 51-56. |